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At 100 days after transplantation, the overall survival rate was just 58.3%, compared with 80.5% for patients who did not develop encephalitis.
High-dose antiviral therapy was shown to mitigate high mortality rates in these patients.
The authors believe that MRV will be a useful mouse model to study the impact of HHV-6 & 7 in humans.
Virologists led by Serge Barcy, Ph D at the Seattle Children’s Research Institute and University of Washington have identified a homolog for HHV-7 in pigtail macaques They were surprised to learn that it could be detected in the peripheral nerve ganglia, and hope to use their new animal model to explore how HHV-7 might play a role in demyelinating diseases.
A Stanford group was also funded to develop whole genome sequencing platform to study HHV-6 and four other viruses post-transplant.
Swedish investigators have found HHV-6 protein in the pancreatic islet cells of both type 1 diabetes patients and controls.
They found variations in specific antiviral genes that correlate with HHV-6 DNA levels in brain tissue and blood from patients with Alzheimer’s disease.A single infusion produced a complete or partial response rate of 92%.